Tampa struck first in the bottom of the fifth against Red Sox starter Aaron Cook. With runners on first and third with one out, Ryan Roberts grounded into a fielder’s choice, giving the Rays a 1-0 lead. As Cobb had only given up one walk through five, it seemed as though that may have been all the support he needed.
Unfortunately, Boston bounced back in the top of the sixth. With one out, Cobb plunked Jose Iglesias with the first pitch of the at bat. Following a ground out and a wild pitch that put Iglesias on third, Jacoby Ellsbury broke up the no hitter by hitting a two run home run, giving the Red Sox a 2-1 lead.
The wheels came off for the Rays in the top of the seventh. Cobb was unable to record an out as the Rays used four pitchers in the inning as the Red Sox used an error, two walks, and three hits to put three more runs on the board. Pinch hitter Mauro Gomez had a two run single with the bases loaded, and Ellsbury chipped in another RBI single.
Tampa attempted to rally in the bottom of the ninth. B.J. Upton led off with a base hit, then took second on defensive indifference. After a wild pitch moved him to third, Ben Zobrist drove him in with a groundout. However, the Red Sox shut down the Rays final two batters in taking the first game of the series 5-2.
Cobb ended his night by giving up four runs on two hits, three walks, and a hit batter, striking out four in his six innings of work. Upton was 3-4 with a run scored in the loss.